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N’N’ Dicyclohexyl Carbodiimide (1,3 DCC)

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N,N’-Dicyclohexylcarbodiimide (1,3-DCC) is a premium reagent extensively utilized in organic chemical synthesis, particularly for efficient peptide bond formation through amide coupling. This white crystalline solid is prized for activating carboxylic acids to generate highly reactive intermediates that promote the synthesis of peptides and esters. The reagent is also effective in dehydration reactions, increasing its versatility in complex organic synthesis workflows. While handling, special attention is required to manage the byproduct dicyclohexylurea which can pose challenges in purification steps. This 25 kg HDPE drum packaged chemical ensures industrial-scale availability for laboratories and manufacturing units focusing on pharmaceutical intermediates, peptide synthesis, or esterification processes. Its solubility in dichloromethane and DMF solvents further adds to its utility in various organic reaction conditions.

Key Features

Features Description
Chemical Name N,N'-Dicyclohexylcarbodiimide (1,3-DCC)
Physical Form White Crystalline Solid
Primary Use Peptide Synthesis and Amide Bond Formation
Additional Applications Esterification and Dehydration Reactions
Byproduct Dicyclohexylurea (requires careful removal)
Packaging 25 kg HDPE Drum
Solubility Soluble in Dichloromethane and DMF
Storage Condition Store in Cool, Dry Place; Avoid Moisture
Safety Information Skin Sensitizer; Use PPE During Handling
Attributes Description
CAS Number 538-75-0
Molecular Formula C13H22N2
Molecular Weight 206.33 g/mol
Appearance White Crystalline Solid
Purity Typically > 99%
Storage Temperature 15°C to 25°C
Handling Precautions Avoid moisture and direct sunlight; Wear appropriate PPE
Chemical Stability Stable under recommended storage conditions
Packaging Details Sealed 25 kg HDPE Drum

*Disclaimer: The above description has been AI-generated and has not been audited or verified for accuracy. It is recommended to verify product details independently before making any purchasing decisions.

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The primary byproduct is dicyclohexylurea which can precipitate and complicate purification. It is advisable to use filtration or recrystallization techniques post-reaction to effectively remove this byproduct. Additionally, optimizing reaction conditions can minimize its formation.

Yes, the product is available in 25 kg HDPE drums ensuring sufficient quantity and consistent quality suited for industrial-scale peptide synthesis and related applications in pharmaceuticals.

This DCC reagent is soluble in organic solvents such as dichloromethane (DCM) and dimethylformamide (DMF), facilitating its use in various organic synthesis protocols.

It should be stored in a cool, dry place away from moisture and direct sunlight, preferably between 15°C to 25°C, to maintain its chemical stability and reactivity.

As a skin sensitizer, appropriate personal protective equipment (PPE) such as gloves, lab coat, and eye protection should be worn. Work in a well-ventilated area or fume hood to minimize exposure.

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Country Of Origin: India

N,N′-Dicyclohexylcarbodiimide is a widely used reagent in organic chemistry, especially for peptide synthesis, where it facilitates amide bond formation. It is a white crystalline solid and operates via activation of carboxylic acids to form stable intermediates. DCC is also used in esterification and dehydration reactions. Care is required as the byproduct, dicyclohexylurea, can be difficult to remove.

N,N′-Dicyclohexylcarbodiimide (1,3-DCC)


Product Summary:

  • CAS Number: 538-75-0

  • Molecular Formula: C13H22N2

  • Molecular Weight: 206.33 g/mol

  • Synonyms: DCC

  • Packaging: 25 kg HDPE drum or packets or bags

  • Solubility: Soluble in dichloromethane, DMF

  • Storage: Cool, dry place; avoid moisture

  • Toxicity: Skin sensitizer; use PPE

Applications:

  • Peptide and amide synthesis

  • Coupling agent for esters

  • Facilitates amide bond formation in pharmaceutical manufacturing
  • Esterification and amidation reactions in organic synthesis
  • Preparation of polymers and dendrimers
  • Precursor for agrochemicals
  • Coupling agent in peptide synthesis




N

N'-Dicyclohexylcarbodiimide

1

3-DCC

Peptide Synthesis Reagent

Amide Bond Catalyst

Carbodiimide Coupling Agent

Organic Synthesis Chemical

Esterification Reagent

Dehydration Reaction Chemical

Dicyclohexylurea Byproduct

N’N’ Dicyclohexyl Carbodiimide (1,3 DCC)

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avd pharmaceuticals private limited

Pimpri-Chinchwad , India

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