Ethyl-4-Chloro acetoacetate is a specialized chlorinated ester derivative of acetoacetic acid, widely valued as a versatile chemical intermediate in pharmaceutical and fine chemical industries. The molecule features a chloro substituent at the γ-position, which endows it with selective reactivity, making it highly suitable for targeted nucleophilic substitution and ring-forming reactions. It serves as a critical building block in the synthesis of biologically significant heterocyclic compounds such as pyrazoles and pyridines, which are core structures in many pharmaceuticals and agrochemicals. Its miscibility with most organic solvents facilitates easy integration into various synthetic pathways. Packaged in industrial-grade 200 kg HDPE drums, Ethyl-4-Chloro acetoacetate is optimized for large-scale chemical manufacturing processes. Due to its chemical nature, it must be handled with care to prevent exposure risks associated with ingestion or inhalation. Overall, this compound is indispensable to manufacturers looking to create complex heterocyclic frameworks, insecticidal agents, fungicides, and fine chemicals with high purity and efficiency.
Key Features
| Features | Description |
|---|---|
| Chemical Structure | Chlorinated acetoacetic acid ester with chloro substituent at γ-position |
| Reactivity | Selectively facilitates nucleophilic substitution and ring-forming reactions |
| Applications | Synthesis of heterocycles such as pyrazoles and pyridines, pharmaceuticals, agrochemicals |
| Packaging | Available in 200 kg HDPE drums for industrial use |
| Solubility | Miscible with most organic solvents |
| Safety | Harmful if ingested or inhaled; requires careful handling |
| Molecular Weight | 164.59 g/mol |
| CAS Number | 4044-65-9 |
| Synonym | Ethyl 4-chloro-3-oxobutanoate |
| Attributes | Description |
|---|---|
| Molecular Formula | C6H9ClO3 |
| CAS Number | 4044-65-9 |
| Molecular Weight | 164.59 g/mol |
| Physical State | Liquid |
| Storage Conditions | Store in a cool, dry area away from incompatible materials |
| Packing | 200 kg HDPE drum |
| Solubility | Miscible with most organic solvents |
| Hazard Information | Harmful if ingested or inhaled |
*Disclaimer: The above description has been AI-generated and has not been audited or verified for accuracy. It is recommended to verify product details independently before making any purchasing decisions.
The γ-position chloro substituent provides a reactive site enabling selective nucleophilic substitution and ring-closing reactions essential for constructing heterocyclic frameworks like pyrazoles and pyridines.
Yes, it is supplied in 200 kg HDPE drums suitable for industrial scale synthesis and manufacturing of pharmaceutical intermediates and fine chemicals.
Ethyl-4-Chloro acetoacetate is miscible with most organic solvents, facilitating its use in diverse synthetic reactions without solubility limitations.
It should be stored in a cool, dry area away from incompatible substances to preserve its chemical stability and prevent degradation.
Given its harmful effects if ingested or inhaled, OSHA-approved protective gear like gloves and respirators are recommended during handling to minimize exposure.
Country Of Origin: India
Ethyl-4-chloroacetoacetate is a chlorinated derivative of acetoacetic acid ester and serves as an important building block in the synthesis of heterocycles and pharmaceuticals. The compound offers selective reactivity due to the presence of a chloro substituent at the γ-position, facilitating ring-forming reactions and nucleophilic substitutions. It finds wide application in the synthesis of pyrazoles, pyridines, and other biologically active scaffolds.
Description:
Ethyl-4-chloroacetoacetate is a chlorinated derivative of acetoacetic acid ester and serves as an important building block in the synthesis of heterocycles and pharmaceuticals. The compound offers selective reactivity due to the presence of a chloro substituent at the γ-position, facilitating ring-forming reactions and nucleophilic substitutions. It finds wide application in the synthesis of pyrazoles, pyridines, and other biologically active scaffolds.
Product Summary:
CAS Number: 4044-65-9
Molecular Formula: C6H9ClO3
Molecular Weight: 164.59 g/mol
Synonyms: Ethyl 4-chloro-3-oxobutanoate
Packaging: 200 kg HDPE drum
Solubility: Miscible with most organic solvents
Storage: Keep in cool, dry area
Toxicity: Harmful if ingested or inhaled
Applications:
Synthesis of pharmaceuticals and fine chemicals
Intermediate for heterocyclic compounds
Starting material for insecticides and fungicides
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