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DFTA (2,4-Difluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone) is an essential chemical intermediate in the industrial production of the antifungal pharmaceutical Fluconazole. This compound plays a critical role in the assembly of Fluconazole's pharmacophore, owing to its unique fluorinated aromatic structure combined with the reactive triazole ring. The presence of dual fluorine atoms enhances its chemical reactivity and selectivity, making it ideal for precise synthetic pathways in antifungal drug development. DFTA is primarily utilized in the active pharmaceutical ingredient (API) manufacturing process under strict controlled conditions to maintain stability due to its chemical sensitivity. It is soluble in solvents like acetone and dichloromethane and is supplied in 25 kg fiber drums suitable for bulk commercial use. Due to possible irritation risks, handling precautions are necessary. This intermediate is not only pivotal for Fluconazole synthesis but serves as a valuable compound in research for novel triazole-based antifungal agents.
Key Features
| Features | Description |
|---|---|
| Chemical Identity | 2,4-Difluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone |
| Role | Key intermediate in Fluconazole antifungal drug synthesis |
| Molecular Formula | C10H7F2N3O |
| Molecular Weight | 223.18 g/mol |
| Chemical Structure | Contains triazole ring and fluorinated aromatic group |
| Solubility | Soluble in acetone and dichloromethane |
| Packaging | 25 kg fiber drum |
| Storage Conditions | Store in dry, cool environment |
| Usage | Used under controlled environments for API production |
| Safety | May cause irritation; handle with proper protective equipment |
| Attributes | Description |
|---|---|
| CAS Number | 86404-63-9 |
| Synonyms | Fluconazole intermediate |
| Physical State | Solid (powder form) |
| Chemical Sensitivity | High; requires handling under controlled environment |
| Applications | API manufacturing of Fluconazole; research for triazole antifungal agents |
*Disclaimer: The above description has been AI-generated and has not been audited or verified for accuracy. It is recommended to verify product details independently before making any purchasing decisions.
DFTA’s unique structural features, including a dual fluorinated aromatic ring and a triazole moiety, are essential for forming the pharmacophore responsible for Fluconazole’s antifungal activity, enabling targeted reactivity and selectivity in the synthesis.
DFTA must be stored in a dry, cool environment to protect its chemical integrity and prevent degradation, due to its chemical sensitivity.
DFTA is soluble in organic solvents such as acetone and dichloromethane, which facilitates its application in various synthetic procedures.
Due to its potential to cause irritation, DFTA should be handled with appropriate protective equipment in a controlled environment to avoid direct exposure.
While primarily used in Fluconazole API synthesis, DFTA also serves as a valuable intermediate in the research and development of other triazole-based antifungal agents.
It is supplied in 25 kg fiber drums, suitable for bulk industrial handling and distribution.
Country Of Origin: India
Description:
DFTA, or 2,4-Difluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone, is a key intermediate in the synthesis of the antifungal drug Fluconazole. This compound is crucial in constructing the pharmacophore responsible for Fluconazole's antifungal activity. It possesses a triazole ring and fluorinated aromatic structure, which contribute to its high reactivity and selectivity in targeted synthesis pathways. DFTA is primarily used in API production under controlled environments due to its chemical sensitivity.
Description:
DFTA, or 2,4-Difluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone, is a key intermediate in the synthesis of the antifungal drug Fluconazole. This compound is crucial in constructing the pharmacophore responsible for Fluconazole's antifungal activity. It possesses a triazole ring and fluorinated aromatic structure, which contribute to its high reactivity and selectivity in targeted synthesis pathways. DFTA is primarily used in API production under controlled environments due to its chemical sensitivity.
Product Summary:
CAS Number: 86404-63-9
Molecular Formula: C10H7F2N3O
Molecular Weight: 223.18 g/mol
Synonyms: Fluconazole intermediate
Packaging: 25 kg fiber drum
Solubility: Soluble in acetone, dichloromethane
Storage: Store in a dry, cool environment
Toxicity: Handle with care; may cause irritation
Applications:
Intermediate in Fluconazole synthesis
Research in triazole-based antifungals
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Pimpri-Chinchwad , India
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