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Cefotaxime Sodium & Sulbactam for Injection 375 mg is a potent combination antibiotic designed for the treatment of a wide spectrum of bacterial infections, including those caused by beta-lactamase producing bacteria. The formulation comprises Cefotaxime Sodium, a third-generation cephalosporin antibiotic, paired with Sulbactam Sodium, a beta-lactamase inhibitor that enhances antibacterial efficacy by preventing enzymatic degradation of Cefotaxime by resistant bacteria. This synergistic duo is ideal for treating severe infections such as respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, septicemia, and bacterial meningitis. Supplied as a sterile dry powder suitable for injection, this product allows convenient reconstitution for intravenous or intramuscular administration in clinical settings. Its carefully balanced dose—typically 250 mg of Cefotaxime Sodium combined with 125 mg of Sulbactam Sodium—ensures an optimal antibacterial effect while minimizing the risk of resistance development. This has made it a preferred injectable antibiotic in hospitals and healthcare institutions involved in managing complex infections requiring broad-spectrum coverage and beta-lactamase resistance.
Key Features
| Features | Description |
|---|---|
| Form | Dry powder for injection |
| Dosage Strength | 375 mg combined dose |
| Cefotaxime Sodium Content | 250 mg |
| Sulbactam Sodium Content | 125 mg |
| Antibiotic Class | Third-generation cephalosporin with beta-lactamase inhibitor |
| Indications | Respiratory, urinary tract, skin, intra-abdominal infections, septicemia, bacterial meningitis |
| Administration Routes | Intravenous or intramuscular injection |
| Spectrum of Activity | Broad-spectrum with effectiveness against beta-lactamase producing bacteria |
| Sterility | Sterile injectable antibiotic |
| Attributes | Description |
|---|---|
| Chemical Composition | Cefotaxime Sodium 250 mg + Sulbactam Sodium 125 mg per vial |
| Physical Appearance | Sterile white to off-white lyophilized powder |
| Packaging | Single-dose vial |
| Solubility | Reconstitutable with sterile water or appropriate diluent |
| Storage Conditions | Store at 2-8°C, protect from light |
| Shelf Life | Typically 24 months from manufacturing |
| Dosage Forms | Injectable powder for reconstitution |
| Regulatory Compliance | Complies with Indian pharmacopoeia standards |
*Disclaimer: The above description has been AI-generated and has not been audited or verified for accuracy. It is recommended to verify product details independently before making any purchasing decisions.
The combination enhances efficacy by Sulbactam acting as a beta-lactamase inhibitor that protects Cefotaxime from enzymatic degradation by resistant bacteria, extending the antibacterial spectrum.
Yes, this combination is specifically formulated to target infections caused by beta-lactamase producing bacteria, providing broader coverage than Cefotaxime alone.
The product is designed for administration either via intravenous (IV) or intramuscular (IM) injection after reconstitution.
The powder should be reconstituted with sterile water for injection or other approved diluents as per prescribing information to maintain stability and sterility.
It is effective against a wide range of infections including respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, septicemia, and bacterial meningitis.
Cefotaxime Sodium & Sulbactam for Injection 375 mg is a combination antibiotic used to treat a broad range of bacterial infections. The combination of a third-generation cephalosporin and a beta-lactamase inhibitor extends its effectiveness against resistant bacteria.
Key Features:
Form: Dry powder for injection.
Strength: 375 mg (combined dosage of Cefotaxime Sodium and Sulbactam Sodium).
Cefotaxime Sodium: 250 mg (typically).
Sulbactam Sodium: 125 mg (typically).
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