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AMBISOME (Liposomal Amphotericin B Injection) is an advanced antifungal medication designed for the treatment of serious and invasive fungal infections. The product utilizes a liposomal delivery system that encapsulates Amphotericin B, significantly reducing the drug's toxicity while maintaining potent antifungal efficacy. It is primarily prescribed for life-threatening fungal infections such as cryptococcal meningitis, aspergillosis, mucormycosis, and systemic candidiasis. The liposomal formulation allows for targeted drug delivery to infected tissues and improves patient tolerance compared to conventional Amphotericin B formulations. AMBISOME injection is administered intravenously under strict medical supervision, making it ideal for hospital and clinical use in treating immunocompromised patients or those with severe fungal infections.
Key Features
| Features | Description |
|---|---|
| Active Ingredient | Amphotericin B |
| Formulation | Liposomal encapsulation |
| Injection Type | Intravenous (IV) injection |
| Indications | Severe fungal infections including cryptococcal meningitis, aspergillosis, mucormycosis, systemic candidiasis |
| Reduced Toxicity | Lower nephrotoxicity and infusion-related side effects compared to conventional Amphotericin B |
| Dosage Form | Lyophilized powder for reconstitution |
| Packaging | Single-dose vial |
| Storage | Store at 2°C to 8°C, protected from light |
| Administration | Reconstitute with sterile water before IV infusion |
| Therapeutic Class | Antifungal agent |
| Attributes | Description |
|---|---|
| Dosage Strength | 50 mg Amphotericin B per vial |
| Shelf Life | 24 months from the date of manufacture |
| Reconstitution Solvent | Sterile water for injection |
| Packaging Details | Available in carton packs containing 1 vial |
| Storage Conditions | Refrigerated at 2°C to 8°C, avoid freezing |
| Compatibility | Compatible with 5% dextrose solution for IV infusion |
| Manufacturer | Licensed pharmaceutical manufacturer |
| Administration Route | Intravenous infusion only |
| Appearance | Sterile lyophilized powder, white to off-white |
| Pharmacological Action | Binds to ergosterol in fungal cell membranes causing cell death |
*Disclaimer: The above description has been AI-generated and has not been audited or verified for accuracy. It is recommended to verify product details independently before making any purchasing decisions.
AMBISOME uses a liposomal encapsulation technology that reduces toxicity, particularly kidney damage, by targeting delivery of Amphotericin B to fungal cells and minimizing exposure to human cells.
Due to its liposomal formulation which lowers nephrotoxicity, AMBISOME is preferred over conventional Amphotericin B in patients with pre-existing renal issues but should still be administered under careful medical monitoring.
AMBISOME vials must be stored refrigerated between 2°C and 8°C and protected from light. It must not be frozen to maintain potency and stability.
AMBISOME is typically incompatible with normal saline and should be reconstituted and diluted only with sterile water and 5% dextrose solution for IV administration to ensure stability.
AMBISOME is indicated for serious fungal infections including cryptococcal meningitis, invasive aspergillosis, mucormycosis, and systemic candidiasis especially in immunocompromised patients.
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