3D-MPLA-4A, also known as 3-O-deacylated-4'-monophosphoryl lipid A (3-DMPLA) in the 4-acylated form, is a specialized research-grade lipid A derivative derived from the lipopolysaccharide (LPS) of Salmonella minnesota Re595. This variant features a tetra-acyl carbon chain structure and is specifically engineered for immunological research focused on Toll-like receptor 4 (TLR4) signaling. Unlike the highly potent hexa-acyl (6A) MPLA analogs, the 4A form demonstrates minimal activity in human immune cells, making it especially valuable as a molecular probe for studying the structure-activity relationship (SAR) of TLR4 receptors. Because of its reduced immunostimulatory profile, 3D-MPLA-4A is frequently investigated as a potential TLR4 antagonist and a promising therapeutic lead in the development of treatments for autoimmune and allergic diseases. This product is intended for advanced laboratory and preclinical research applications where precise modulation of innate immune responses is required. Its defined molecular structure, research-grade quality, and application in receptor biology make it a relevant choice for immunology laboratories, pharmaceutical R&D teams, and biotechnology researchers studying inflammatory pathways, receptor binding, and immune regulation.

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