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1-Hydroxybenzotriazole monohydrate (HOBt Monohydrate) is a white crystalline solid widely used as a highly efficient coupling reagent in peptide synthesis and various organic transformations. Its primary function is to enhance the formation of amide bonds by significantly suppressing racemization and stabilizing reactive active esters, which ensures higher reaction yields and peptide purity. This specific monohydrate form offers superior handling characteristics, improved stability, and better solubility in solvents like DMF, DMSO, and methanol compared to the anhydrous form, making it ideal for pharmaceutical research and industrial peptide manufacturing environments. The product is available in 25 kg fiber drums or HDPE containers, designed for bulk use in laboratories and large-scale production. Due to its chemical properties, 1-Hydroxybenzotriazole monohydrate requires stringent safety precautions to prevent explosive decomposition from heat or friction, underlining the importance of controlled storage and handling. Extensively utilized as a key intermediate in drug synthesis and advanced organic chemistry research, this reagent supports the synthesis of complex molecules in pharmaceutical development pipelines and other specialized chemical manufacturing processes.
Key Features
| Features | Description |
|---|---|
| Chemical Identity | 1-Hydroxybenzotriazole Monohydrate (HOBt·H2O) |
| Appearance | White crystalline solid |
| Primary Use | Coupling reagent for peptide synthesis |
| Racemization Suppression | Effectively reduces racemization during amide bond formation |
| Solubility | Soluble in DMF, DMSO, methanol |
| Packaging | Available in 25 kg fiber drums or HDPE containers |
| Molecular Weight | 155.14 g/mol |
| Handling | Requires strict safety precautions due to explosive decomposition risk |
| Storage Conditions | Store in a cool, dry place away from oxidizers |
| Applications | Used in pharmaceutical R&D, industrial peptide manufacturing, and drug synthesis |
| Attributes | Description |
|---|---|
| CAS Number | 123333-53-9 |
| Molecular Formula | C6H5N3O·H2O |
| Appearance | White crystalline solid |
| Solubility | Soluble in DMF, DMSO, methanol |
| Packaging Options | 25 kg fiber drum or HDPE container |
| Storage | Cool, dry place, away from oxidizers |
| Molecular Weight | 155.14 g/mol |
| Toxicity | May cause irritation; handle with care |
| Stability | Stable under recommended storage; avoid heat and friction |
*Disclaimer: The above description has been AI-generated and has not been audited or verified for accuracy. It is recommended to verify product details independently before making any purchasing decisions.
The monohydrate form of HOBt offers improved handling characteristics and better solubility in common organic solvents such as DMF, DMSO, and methanol, facilitating easier dissolution during peptide coupling reactions. Additionally, it tends to be more stable and safer to handle than the anhydrous form under industrial manufacturing conditions.
1-Hydroxybenzotriazole monohydrate stabilizes intermediate active esters formed during the coupling step, which minimizes epimerization or racemization of chiral centers by reducing the lifetime of reactive intermediates susceptible to stereochemical inversion.
Due to its potential for explosive decomposition when exposed to heat or friction, strict safety protocols including storage in a cool, dry area away from oxidizing agents, use of protective equipment, controlled handling procedures, and proper ventilation must be observed.
This compound is primarily used in pharmaceutical research and development, industrial peptide manufacturing, and as an intermediate in drug synthesis and other organic chemical processes.
HOBt monohydrate shows high solubility in solvents like N,N-Dimethylformamide (DMF), Dimethyl sulfoxide (DMSO), and methanol, which are commonly used in peptide coupling and related organic synthesis processes.
Country Of Origin: India
Description:
1-Hydroxybenzotriazole monohydrate is a white crystalline solid commonly used as a coupling reagent in peptide synthesis and other organic transformations. It enhances the efficiency of amide bond formation by suppressing racemization and stabilizing active esters. This hydrated form is particularly favored for its better handling characteristics and ease of dissolution. It is used extensively in pharmaceutical R&D and industrial peptide manufacturing. Due to its potential for explosive decomposition under heat or friction, it must be handled with strict safety precautions.
Description:
1-Hydroxybenzotriazole monohydrate is a white crystalline solid commonly used as a coupling reagent in peptide synthesis and other organic transformations. It enhances the efficiency of amide bond formation by suppressing racemization and stabilizing active esters. This hydrated form is particularly favored for its better handling characteristics and ease of dissolution. It is used extensively in pharmaceutical R&D and industrial peptide manufacturing. Due to its potential for explosive decomposition under heat or friction, it must be handled with strict safety precautions.
Product Summary:
CAS Number: 123333-53-9
Molecular Formula: C6H5N3O·H2O
Molecular Weight: 155.14 g/mol
Synonyms: HOBt·H2O
Packaging: 25 kg fiber drum or HDPE container
Solubility: Soluble in DMF, DMSO, methanol
Storage: Store in cool, dry place, away from oxidizers
Toxicity: May cause irritation; handle with care
Applications:
Coupling reagent in peptide synthesis
Intermediate in drug synthesis
Research and development in organic chemistry
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Pimpri-Chinchwad , India
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