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1-Hydroxybenzotriazole Anhydrous (HOBt Anhydrous) is an essential reagent widely utilized in advanced pharmaceutical and chemical synthesis specifically targeting peptide bond formation. This high-purity, moisture-sensitive anhydrous compound acts as a potent acylation catalyst and condensation agent, significantly enhancing the efficiency of carbodiimide-mediated coupling reactions by preventing racemization and improving overall reaction yields. Its ability to operate under strictly anhydrous conditions makes it indispensable for the synthesis of pharmaceutical peptides, esters, and complex small molecules. Packaged safely in 25 kg fiber drums and soluble in polar organic solvents, HOBt Anhydrous demands careful storage within dry and inert atmospheres due to its sensitive and potentially explosive nature when dry. Its specialized application in pharmaceutical R&D and peptide synthesis processes establishes it as a critical reagent for professional laboratories and industrial-scale peptide manufacturers.
Key Features
| Features | Description |
|---|---|
| Chemical Name | 1-Hydroxybenzotriazole Anhydrous (HOBt Anhydrous) |
| Primary Use | Peptide bond formation and acylation catalyst |
| Role | Prevents racemization and improves yields in carbodiimide-mediated coupling |
| Physical Form | Anhydrous, moisture-sensitive powder |
| Packaging | 25 kg fiber drum |
| Solubility | Soluble in polar organic solvents |
| Storage Requirements | Store in dry, inert atmosphere; handle carefully due to explosive nature when dry |
| Applications | Pharmaceutical peptide synthesis, ester synthesis, activated carboxylic derivatives |
| CAS Number | 2592-95-2 |
| Molecular Weight | 135.12 g/mol |
| Attributes | Description |
|---|---|
| Molecular Formula | C6H5N3O |
| CAS Number | 2592-95-2 |
| Physical State | Solid, crystalline powder |
| Purity | High purity, anhydrous grade |
| Storage Conditions | Store under inert gas in dry environment |
| Hazard Information | Explosive when dry; requires controlled handling |
| Recommended Usage | Use under strictly anhydrous conditions for optimal performance |
| Solubility | Soluble in polar organic solvents such as DMF, DMSO |
| Packaging Details | Available in 25 kg fiber drums to maintain integrity and safety |
*Disclaimer: The above description has been AI-generated and has not been audited or verified for accuracy. It is recommended to verify product details independently before making any purchasing decisions.
The anhydrous form of 1-Hydroxybenzotriazole is significantly more reactive and moisture-sensitive, making it suitable for strictly anhydrous peptide synthesis conditions where high-purity and improved coupling efficiency are required. Its use minimizes side reactions and racemization compared to hydrated forms.
Because 1-Hydroxybenzotriazole Anhydrous is explosive when dry, it must be handled under controlled conditions with proper personal protective equipment, in a dry and inert atmosphere, avoiding friction, heat, or contamination with incompatible materials.
It is highly soluble in polar organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), which are commonly used in peptide coupling reactions for better reagent performance.
HOBt Anhydrous is typically supplied in 25 kg fiber drums designed to maintain the chemical's anhydrous condition and ensure safe transportation and storage for industrial and professional lab environments.
It is most valuable in pharmaceutical peptide synthesis, ester synthesis, and the generation of activated carboxylic derivatives where racemization prevention and high coupling yields are crucial.
Country Of Origin: India
1-Hydroxybenzotriazole anhydrous is a potent acylation catalyst and condensation agent used primarily in peptide bond formation. It prevents racemization and improves yields in carbodiimide-mediated coupling reactions. The anhydrous form is highly reactive and moisture-sensitive, often used in strictly anhydrous conditions for high-purity synthesis. It is valuable in the synthesis of pharmaceutical peptides, esters, and complex small molecules.
Description:
1-Hydroxybenzotriazole anhydrous is a potent acylation catalyst and condensation agent used primarily in peptide bond formation. It prevents racemization and improves yields in carbodiimide-mediated coupling reactions. The anhydrous form is highly reactive and moisture-sensitive, often used in strictly anhydrous conditions for high-purity synthesis. It is valuable in the synthesis of pharmaceutical peptides, esters, and complex small molecules.
Product Summary:
CAS Number: 2592-95-2
Molecular Formula: C6H5N3O
Molecular Weight: 135.12 g/mol
Synonyms: HOBt
Packaging: 25 kg fiber drum
Solubility: Soluble in polar organic solvents
Storage: Store in a dry, inert atmosphere
Toxicity: Explosive when dry; handle under controlled conditions
Applications:
Amide bond formation in peptide synthesis
Synthesis of esters and activated carboxylic derivatives
Pharmaceutical R&D
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Pimpri-Chinchwad , India
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