VAISHNAVI INJECTABLES

BQNAT = Bedaquiline-based treatment following a Negative CBNAAT test

CBNAAT = Cartridge-Based Nucleic Acid Amplification Test (like GeneXpert)

BQNAT regimen is used for drug-resistant TB cases when:

Rifampicin resistance is detected

Patient is eligible for Bedaquiline-containing regimen

Confirmed MDR-TB or XDR-TB, often through Line Probe Assay (LPA) and CBNAAT

BQNAT Regimen – Overview (India’s NTEP Guidelines)

Core Drugs (may vary slightly):

Bedaquiline (BDQ)

Levofloxacin (Lfx) or Moxifloxacin (Mfx)

Linezolid (Lzd)

Clofazimine (Cfz)

Cycloserine (Cs)

Duration: 18–20 months, depending on patient response and tolerability

Regular monitoring: ECG, liver function, electrolytes, adherence

Used In:

Patients with rifampicin-resistant TB (RR-TB) or MDR-TB

If CBNAAT detects Rif resistance, and DST (Drug Susceptibility Testing) guides further drug inclusion

Implemented under National TB Elimination Program (NTEP), India

If you're referring to something else by BQNAT (e.g., a lab test, a program, or a specific guideline), feel free to clarify!

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Sofosbuvir + Velpatasvir Tablet – Summary

Brand Names:

VELPANAT (by Natco Pharma)

Epclusa (international brand by Gilead Sciences)

Drug Class:

Direct-Acting Antiviral Agents (DAAs)

NS5B polymerase inhibitor (Sofosbuvir)

NS5A inhibitor (Velpatasvir)

Composition:

Each tablet contains:

Sofosbuvir 400 mg

Velpatasvir 100 mg

Indications / Uses:

Treatment of Chronic Hepatitis C Virus (HCV) infection in adults and children (≥6 years or ≥17 kg)

Effective against all major HCV genotypes (1–6)

Mechanism of Action:

Sofosbuvir inhibits the HCV RNA-dependent RNA polymerase (NS5B), stopping viral replication.

Velpatasvir inhibits the NS5A protein, crucial for viral replication and assembly.

Combined, they block multiple steps in the HCV replication cycle, achieving high cure rates.

Dosage & Administration:

1 tablet once daily with or without food

Duration: Typically 12 weeks

In patients with cirrhosis, ribavirin may be added, depending on the case

Side Effects:

Common:

Fatigue

Headache

Nausea

Insomnia

Serious (rare):

Bradycardia (especially with amiodarone)

Liver enzyme elevations

Reactivation of hepatitis B (in co-infected patients)

Precautions:

Screen for Hepatitis B before initiating treatment

Use caution in severe renal impairment

Not recommended during pregnancy (especially with ribavirin)

Avoid use with strong P-gp or CYP inducers (e.g., rifampin, St. John's Wort)

Drug Interactions:

Amiodarone (risk of serious bradycardia)

Rifampin, carbamazepine, phenytoin (reduce effectiveness)

Antacids (may affect velpatasvir absorption — take separately)

Storage:

Store below 30°C

Keep in original container away from moisture

Effectiveness:

Cure rates (SVR12) above 95% for all HCV genotypes

Pan-genotypic, meaning no need for genotype testing in many cases

Let me know if you'd like a patient-friendly leaflet, PDF summary, or comparison with other Hep C treatments like Sofosbuvir + Daclatasvir.

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